Destabilization of medial meniscus

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August undefined, 2024

WebFeb 22, 2024 · To fill this knowledge gap, we examined the effect of intragastric and intraarticular metformin in an destabilization of the medial meniscus (DMM) model of OA in mice, known to cause destabilization of the joint which eventually leads to degeneration and pain of the joint, and investigated whether the anabolic and anti-catabolic effects of … Webdifferences in a destabilized medial meniscus osteoarthritis model. Methods: Male and Female mice receive either a destabilized medial meniscus or sham procedure resulting …

Mouse models of osteoarthritis: surgical model of

WebDestabilization of the medial meniscus (DMM) was performed on the right knees of 2 month-old male Matn1-/- (n = 11) and Matn1+/+ (n = 9) mice. A) mRNA levels of type II collagen (Col2a1) and... WebNov 11, 2024 · Mice subjected to surgery for destabilization of the medial meniscus (OA group) or control surgery (Control group) were sacrificed after eight weeks. The knees were collected for histological assessment. normal weight 5\u00274 female

Destabilization of the Medial Meniscus (DMM) in Rats …

WebOsteoarthritis Mouse Model of Destabilization of the Medial Meniscus This chapter describes the surgical procedure for destabilization of medial meniscus in mice. Details on subsequent microCT and histological analysis are also provided, as well as details on osteoarthritis evaluation. WebJan 1, 2015 · Destabilization of the medial meniscus (DMM) surgery and tissue processing post-DMM. DMM surgeries were performed, as described 32, 33 , in 12-week-old male IKKα cKO and WT littermates. Power... WebFeb 9, 2024 · Age is the primary risk factor for osteoarthritis (OA), yet surgical OA mouse models such as destabilization of the medial meniscus (DMM) used for evaluating … normal weight 5\u00275 woman

Mouse Models of Osteoarthritis: Surgical Model of

Exploration of metformin as novel therapy for osteoarthritis ...

WebSep 29, 2016 · Then we induced OA in rats through surgical destabilization of the medial meniscus (DMM), and evaluated the effects of AMD3100 on the progression of OA and aggrecan metabolism. Third, we cultured rat primary chondrocytes with untreated control, CXCL12a, siNC + CXCL12a, or siRNA CXCR4 + CXCL12a and confirmed ACAN, SOX … WebApr 10, 2024 · In this study, a destabilization of the medial meniscus (DMM)-induced OA model was constructed, and SDF-1α expression in the OA model was evaluated. The CXCR4 receptor antagonist AMD3100 was used to block SDF-1α, and changes in subchondral bone and the expression of BMSCs in subchondral bone in the OA model … normal weight 5\\u00274 womanWebNational Center for Biotechnology Information normal weight 5\u00278

"WebSep 1, 2007 · A: Surgical approach to the right mouse knee joint with a medial para-patellar ligament incision; B: Following fat pad blunt dissection the medial meniscus (MM) and … " - Destabilization of medial meniscus

Destabilization of medial meniscus

Silencing of NOTCH3 Signaling in Meniscus Smooth Muscle Cells …

WebDestabilization of medial meniscus (DMM) model is an important tool for studying the pathophysiological roles of numerous arthritis associated molecules in the pathogenesis of osteoarthritis (OA) in vivo. However, the detailed, especially the visualized protocol for establishing this complicated model in mice, is not available. WebMay 1, 2024 · Conclusions. We developed medial meniscus extrusion in a rat model, and centralization of the extruded medial meniscus by the pull-out suture technique improved the medial meniscus extrusion and delayed cartilage degeneration, though the effect was limited. Centralization is a promising treatment to prevent the progression of osteoarthritis.

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WebFeb 9, 2024 · Age is the primary risk factor for osteoarthritis (OA), yet surgical OA mouse models such as destabilization of the medial meniscus (DMM) used for evaluating … WebFeb 9, 2024 · Age is the primary risk factor for osteoarthritis (OA), yet surgical OA mouse models such as destabilization of the medial meniscus (DMM) used for evaluating disease-modifying OA targets are ...

WebFeb 12, 2024 · The DMM (destabilization of the medial meniscus) model is now the most commonly used surgical model in mice. Its reliability, reproducibility, structural similarity to human OA, its relatively... WebIn the µCT analysis, destruction of the medial tibial plateau was observed in 4/40 knees, while none were observed in the DMM group. Of the four knees, destruction of the …

WebExperimental OA was induced in 12-week-old male mice (C57BL/6J) by destabilization of the medial meniscus (DMM) surgery as described by Glasson et al. . The medial meniscus tibial ligament was exposed without sectioning in sham surgery. Mice were sacrificed 8 weeks after DMM or sham surgery and subjected to histological analyses. WebMar 29, 2024 · When the destabilization of the medial meniscus (DMM) osteoarthritis model was induced in RUNX2 knockout mice, the gene expression of matrix degradation …

WebApr 7, 2024 · 按文献方法采用内侧半月板失稳(destabilization of medial meniscus，DMM)手术诱导建立KOA模型[9]，简述如下：右膝关节内侧髌韧带与内侧副韧带之间开0.5 cm切口，显微镜下暴露、剪断内侧半月板胫骨韧带，缝合切口。

WebFeb 10, 2024 · We further investigated whether kindlin-2 loss impacts progression of a destabilization of the medial meniscus (DMM)-induced OA model. At 2 months of age, the K2fl/fl; AggrecanCreERT2 mice were... normal weight 5\\u00278WebMar 22, 2024 · 22 Mar 2024 All issues ONLINE COVER Mind the gp130. In this image of a mouse knee joint after medial meniscus destabilization, Safranin O staining reveals proteoglycan-rich cartilage (pink) at the joint surface, suggesting resistance to osteoarthritis. normal weight 5\u0027 8 maleWebApr 7, 2024 · This might be related to the study model, since destabilization of the medial meniscus model can quickly lead to osteoarthritis, but non-traumatic osteoarthritis is a slow progress. While NOTCH3 activation was shown to promote chondrogenic differentiation, ... normal weight 5\u00278 femaleWebDesign: Acomys received destabilization of the medial meniscus (DMM) surgery (n = 11) or a skin incision (n = 10). Gait testing occurred at 4, 6, 8, 10, and 12 weeks after surgery. At endpoint, joints were processed for histology to assess cartilage damage. Results: Following joint injury, Acomys with DMM surgery altered their walking patterns ... normal weight 5 year oldWebApr 6, 2024 · Tryptase β regulation of joint lubrication and inflammation via proteoglycan-4 in osteoarthritis - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. normal weight 5\u00277 maleWebFeb 8, 2024 · This chapter describes the surgical procedure for destabilization of medial meniscus in mice. Details on subsequent microCT and histological analysis are also … normal weight 60 year old manhttp://jur.byu.edu/?p=1626 normal weight 65 year old woman