Dysregulation of lipid metabolism
WebJul 29, 2024 · Notably, neurodegenerative diseases, including Alzheimer’s disease (AD), and Parkinson’s disease (PD), share lipid dysregulation as a metabolic feature in disease pathology. In this review, we discuss evolving knowledge and recent advances in understanding the contribution of LDs to pathogenesis of neurodegenerative diseases. WebMar 1, 2024 · Dysregulation of lipid synthesis or metabolism contribute to the pathogenesis and development of NAFLD. Hyperactivation of mTORC1 signaling pathway is responsible for the activation of SREBP-1c to enhance lipid synthesis and adipocyte in response to nutrient overload.
Dysregulation of lipid metabolism
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WebHigh-resolution lipidomics reveals dysregulation of lipid metabolism in respiratory syncytial virus pneumonia mice† Jinjun Shan, ‡*ab Wenjuan Qian,‡ab Cunsi Shen,‡a Lili Lin,‡ab … WebJan 20, 2024 · This study demonstrated that LPO exposure can induce lipid accumulation and associated metabolic dysregulation in human liver-derived organoids. This provides an innovative model for studying fatty liver disease and testing potential therapeutics. ... Thus, the exact role of lipid metabolism in different cell types derived from liver organoids ...
WebJul 29, 2024 · Autophagy modulates major pathological changes, including hepatic lipid metabolism, inflammation, and fibrosis, suggesting the potential of modulating autophagy …
WebMar 22, 2024 · The term “lipid disorder” covers a range of conditions that can cause abnormal levels of lipids, or fats, in the blood. These fats include low-density lipoproteins … WebThree molecules play key roles in the regulation of triglyceride metabolism: apolipoprotein C-III(ApoC-III), angiopoietin-like protein 4(ANGPLT4), and lipoprotein lipase(LPL). The aim of this work was to analyze whether the changes in triglycerides shown by TCZ-treated RA patients could stem from the dysregulation that can occur in these ...
WebAltogether, research in the field of pulmonary fibrosis continues to suggest that metabolic dysregulation acts as a key contributor to the pathogenesis of the disease, and that drugs targeting different aspects of cellular metabolism, including glycolysis, mitochondrial oxygen consumption, and lipid metabolism, should be strongly considered for ...
WebWe used bioinformatic analysis and examined changes in lipid metabolism in HCC cells in response to matrix stiffness. Moreover, ACADL was identified as a key enzyme, initiating … how to keep screen awakeWebThe most discriminant lipidic molecules between the three groups of patients, estimated according to their Variable Importance in Projection (VIP) score (threshold > 2.0) included … how to keep screen awake macWebApr 24, 2024 · Then, metabolism dysregulations were investigated in both patients and murine models. Alterations of elongase and desaturase activities were observed along … how to keep screen awake longerWebA triglyceride level higher than 11.3 mmol/L (1000 mg/dL) usually signifies the presence of two or more abnormalities of lipid metabolism (e.g., estrogen therapy in the presence of … how to keep screen awake windows 11WebJun 9, 2024 · Frontiers Dysregulation of Lipid Metabolism in Macrophages Is Responsible for Severe Endotoxin Tolerance in FcgRIIB-Deficient Lupus Mice View Article Impact … how to keep screen from going offWebDec 16, 2024 · Glucose and lipid metabolic dysregulation in sera of COVID-19 patients. a Fasting blood glucose in the healthy control group and COVID-19 infection and recovery group (HC, healthy control, n... joseph glasgow singerWebJan 1, 2024 · A total of 423 peptides, corresponding to metabolic pathways, ABC transporters, starch and sucrose metabolism, insulin resistance/secretion, fatty digestion and absorption, and lipid metabolism ... how to keep screen from going to sleep