Web1 sep. 2000 · Effects of pretreatment with methoctramine. Methoctramine caused parallel concentration-dependent rightward shifts of carbachol concentration-response curves in bladder strips from both male (Figure 4a) and female (Figure 4b) rats. pA 2 values for methoctramine were similar in bladder strips from males (6.22) and females (6.14) … Web1 dec. 1987 · The antimuscarinic effects of methoctramine (N,N'-bis[6- [(2-methoxybenzyl)amino]hexyl]-1,8-octanediamine tetrahydrochloride) were investigated in vitro in isolated paced left (force) and spontaneously beating right (force and rate) atria of guinea pigs as well as ileum of guinea pig and rat. Methoc …
Methoctramine tetrahydrochloride M2 Muscarinic Receptor …
WebMethoctramine. Methoctramine, a selective M2 antagonist,12 is a useful probe for characterizing acetylcholine muscarinic receptor (mAChR) subtypes. From: The Practice … Web5 jan. 1988 · A newly described cardiac selective antagonist methoctramine was examined in direct binding studies for affinity at three putative subtypes of the muscarinic receptor. The compound proved to be highly selective (158 fold) for cardiac as opposed to exocrine gland type M 2 muscarinic receptors. budget rent a car lubbock airport
Methoctramine - an overview ScienceDirect Topics
Web19 jan. 2007 · Both methoctramine and another M2/M4 antagonist, {11- [ [2- [ (diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido [2,3-b] [1,4]benzodiazepin-6-one} (AF-DX 116), caused a rapid onset and persistent increase in baseline synaptic transmission after i.c.v. injection. WebIn Vitro Methoctramine tetrahydrochloride attenuates Acetylcholine (ACh)- and Arecaidine propargyl ester (APE)-induced increases in PG synthesis in a concentration-dependent manner[1]. Methoctramine (0.01-1 μM) tetrahydrochloride causes facilitation of contractions induced by both pre- and postganglionic WebMethoctramine (300 μg/kg i.v.) strongly inhibited the methacholine- and muscarine-induced bradycardia in the anaesthetized and pithed rat, respectively. The same dose of … budget rent a car long beach ca