Top2a cancer

Author: pcwy

August undefined, 2024

WebHigh expression of TOP2A in many types of tumors, such as non-small cell lung cancer, hepatocellular carcinoma, and breast cancer, has been proven to be a dependable proliferation marker and is ... Web11. nov 2015 · Overexpression of TOP2A is associated with risk of systemic progression in prostate cancer patients, and higher levels of TOP2A were found in hormone-resistant cases. To elucidate the mechanism by which high levels of TOP2A contribute to tumor progression we generated TOP2A overexpressing prostate cancer cell lines. We show …

TOP2A induces malignant character of pancreatic cancer …

Web1. máj 2024 · In addition, TOP2A could be considered as valuable prognostic biomarkers to identify prostatic patients, non-small cell lung cancer and lung cancer (Hou et al., 2024; Labbe et al., 2024; Ma et al., 2024). A study proved that autoantibody against TOP2A could identify lung cancer patients, benign lung disease from normal control (Pei et al., 2024). Web1. máj 2005 · Javier A. Menendez, Luciano Vellon, Eva Horak, Ruth Lupu; DNA Topoisomerase IIα (TOP2A) inhibitors doxorubicin and etopoxide (VP-16) up-regulate Fatty Acid Synthase (FAS) gene expression in SK-Br3 breast cancer cells: In vitro evidence for a “functional amplicon” involving FAS, Her-2/neu and TOP2A genes.Cancer Res 1 May 2005; … stream world cup espn

TOP2A amplification in breast cancer is a predictive …

Web3. aug 2012 · The TOP2A amplification is related to anthracycline-based neoadjuvant chemotherapy sensitivity, and TOP2A should be included in future studies in breast … WebAnthracycline is a DNA topoisomerase 2-α (TOP2A) inhibitor and its concomitant over expression with Human Epidermal Growth Factor Receptor 2 (HER2) was investigated of … WebTOP2A Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, TOP2A Genome Browser, TOP2A References TOP2A - Explore an overview of TOP2A, with a … rowland miller and partners

Expression of TOP2A in liver cancer - The Human Protein Atlas

High expression of TOP2A gene predicted poor prognosis of ...

Web14. apr 2024 · A.C.D. is supported by grants from the American Cancer Society (129755-RSG-16-176-DDC), the National Institutes of Health/National Cancer Institute (2RO1 CA177875 and RO1 CA2558451), the Melanoma ... Web1. apr 2014 · This study investigated the potential ways and consequences of etoposide resistance in MCF-7 breast cancer cells. Etoposide-resistant sublines of MCF-7 developed in our laboratory have been investigated earlier for expression of TOP2A encoding the topoisomerase II isoform and two mismatch repair genes, MLH1 and MSH2. Here, a more … rowland missouriWeb27. mar 2024 · Topoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. The prognostic effect … rowland model 5

"WebTOP2A deletion (gene to chromosome ratio ≤0.8) or monosomy (only one signal for both gene and chromosome in more than 75% of nuclei) were classified as gene loss. Results: … " - Top2a cancer

Top2a cancer

Abstract - American Association for Cancer Research

Web11. sep 2024 · We analyzed the expression profile of TOP2A in various human tumors using Oncomine database, and the results revealed that TOP2A expression was higher in most solid tumors including lung cancer, bladder cancer, brain cancer, breast cancer, digestive tract cancers, liver cancer and many other cancers comparing to their matched normal … Web21. aug 2024 · The aim of the present study was to determine the role of topoisomerase 1 (TOP1) and topoisomerase 2A (TOP2A) in liver cancer (LC), and to investigate the inhibitory effect of nitidine chloride (NC) on these two topoisomerases. Immunohistochemistry (IHC) staining and microarray or RNA sequencing data mining showed markedly higher …

Did you know?

WebPred 1 dňom · Anthracycline plus taxane regimens are most efficacious at reducing breast cancer recurrence and death. Regimens with higher cumulative doses of anthracycline plus taxane provide the greatest benefits, challenging the current trend in clinical practice and guidelines towards non-anthracycline chemotherapy, particularly shorter regimens, such …

WebTOP2, TP2A Topoisomerase (DNA) II alpha (TOP2A) is a gene that encodes a protein that controls and alters topologic states of DNA during transcription. Missense mutations, synonymous mutations, frameshift deletions, nonsense mutations, and frameshift insertions are observed in cancers such as colon cancer, skin cancer, and endometrial cancer. Web3. aug 2012 · Anthracycline is a DNA topoisomerase 2-α (TOP2A) inhibitor and its concomitant over expression with Human Epidermal Growth Factor Receptor 2 (HER2) was investigated of being predictive for the response to anthracycline-based chemotherapies in breast cancer. 309 early and local advanced breast cancer patients were treated with …

Web7. aug 2014 · HER2 and TOP2A genes are coamplified in breast and some other cancers. In this study, we investigated gene aberrations of HER2 and TOP2A and protein expressions … Web11. sep 2024 · Using bioinformatic analysis, we revealed that TOP2A could be adopted as a prognostic indicator of NSCLC and it potentially regulate cancer development through co …

Web11. sep 2024 · We analyzed the expression profile of TOP2A in various human tumors using Oncomine database, and the results revealed that TOP2A expression was higher in most …

Web13. feb 2024 · Relapsed epithelial ovarian cancer (EOC) is frequently treated with pegylated liposomal doxorubicin (PLD). Unfortunately, most patients do not benefit from treatment. Prediction of response is crucial to optimize PLD use and avoid unnecessary toxicities. We aimed at assessing the value of topoisomerase II alpha (TOP2A) expression as predictive … rowland monumentsWeb23. jan 2024 · High levels of TOP2A expression are also detected in diverse human malignancies; these include adrenocortical, nasopharyngeal and gallbladder carcinomas, and cancers of the breast, ovary, oral, … rowland morgan 1508Web8. sep 2014 · Our results indicated that TOP2A was the most highly upregulated gene in recurrent/metastatic prostate cancer, and its high expression was positively correlated with poor prognosis in patients. Using a promoter reporter system, we unexpectedly discovered enrichment of CSCs in TOP2Anegcells. rowland mixer websiteWeb12. sep 2003 · HER-2/NEU is one of the most frequently amplified oncogenes and a potential therapeutic target in bladder cancer. In breast cancer, the adjacent TOP2A gene, the molecular target for several anticancer drugs, is frequently coamplified together with HER-2.Amplifications were most frequently seen in advanced-stage (pT2–4) tumors (HER-2 … rowland mortgageshttp://www.cancerindex.org/geneweb/TOP2A.htm rowland morgan sanford maineWeb1. jan 2024 · TOP2A is an enzyme that controls the topological states of DNA. It catalyzes double-strand DNA breaking and promotes gene transcription during mitosis [3]. It has … rowland morrisWeb12. sep 2003 · To determine the frequency of genomic alterations of HER-2 and TOP2A in bladder cancer, we analyzed the subset of 1,853 tumor samples representing the first … stream world cup 2022 free reddit